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Related Experiment Videos

Patched 1 conditional null allele in mice.

Tammy Ellis1, Ian Smyth, Emily Riley

  • 1Institute for Molecular Bioscience, University of Queensland, Brisbane Queensland, Australia.

Genesis (New York, N.Y. : 2000)
|July 23, 2003
PubMed
Summary

Researchers developed a conditional mouse model to study the patched gene (Ptc), a key player in hedgehog signaling. This tool allows for precise control over Ptc gene function, aiding research into development and cancer.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cancer Biology

Background:

  • The patched gene (Ptc) is crucial for the hedgehog signaling pathway, essential in tissue development.
  • Mutations in Ptc and other hedgehog pathway components are implicated in common human cancers.
  • Ptc acts as the receptor for the hedgehog ligand, and its absence causes embryonic lethality in mice.

Purpose of the Study:

  • To create a conditional Ptc allele in mice.
  • To enable temporospatial ablation of Ptc function.
  • To facilitate research on the role of Ptc in development and disease.

Main Methods:

  • Generation of a conditional Ptc allele in mice.
  • Utilizing genetic tools for targeted gene inactivation.

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Main Results:

  • A conditional Ptc allele was successfully created.
  • This allele allows for controlled inactivation of Ptc function in specific tissues and at specific times.

Conclusions:

  • The conditional Ptc allele provides a valuable tool for studying the gene's function.
  • This model will advance research into the roles of hedgehog signaling in development and cancer.