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[Panic disorder].

T Kuboki1, H Suematsu

  • 1Dept. of Psychosomatic Medicine, Faculty of Medicine, University of Tokyo, Branch Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 1, 1992
PubMed
Summary

This study on panic disorder found that sodium lactate infusion provoked panic attacks in most patients. Abnormal urine catecholamines and respiratory function were also common findings in panic disorder research.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Context:

  • Panic disorder, a distinct diagnostic entity since DSM-III, has a complex etiology.
  • Understanding the physiological and psychological underpinnings of panic attacks is crucial for effective treatment.

Purpose:

  • To conduct a historical review of panic disorder research.
  • To present clinical findings from a study of 7 patients with panic disorder.
  • To investigate physiological correlates and triggers of panic attacks.

Summary:

  • Abnormal dexamethasone suppression tests (DSTs) were found in 2/5 patients.
  • Elevated urinary adrenaline and noradrenaline were observed in 5/6 patients.
  • Caffeine provoked anxiety in 2/5 patients, while sodium lactate infusion triggered panic attacks in 4/7 patients.
  • Abnormal respiratory function was noted in 2/2 patients undergoing treadmill tests.
  • Cardiac abnormalities included T-wave depression in 3/5 patients and sinus tachycardia in 1/3 patients.

Impact:

  • Highlights the heterogeneity of physiological findings in panic disorder.
  • Suggests sodium lactate infusion as a potential provocative agent for panic attacks.
  • Underscores the need for further research into the neurobiological mechanisms of panic disorder.

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