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Updated: Aug 10, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

[Contingent negative deviation in children with headaches]

Z V Cherniak, L R Zenkov, N N Iakhno

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |July 23, 2003
    PubMed

    Insights

    Contingent negative deviation (CND) amplitude was higher in children with migraine compared to those with tension-type headache or controls. This finding suggests CND may aid in diagnosing childhood migraine.

    Area of Science:

    • Neuroscience
    • Pediatric Neurology
    • Clinical Electrophysiology

    Context:

    • Migraine and tension-type headache are common in childhood.
    • Understanding the neurophysiological underpinnings of pediatric headaches is crucial for diagnosis.
    • Contingent negative deviation (CND) is an electrophysiological measure reflecting attention and expectancy.

    Purpose:

    • To investigate differences in Contingent Negative Deviation (CND) between children with migraine, tension-type headache, and healthy controls.
    • To assess the diagnostic potential of CND in childhood migraine.

    Summary:

    • A study compared CND in 26 children with migraine, 20 with tension-type headache, and 16 healthy controls aged 7-14.
    • Children with migraine exhibited a significantly higher negative wave amplitude during CND tasks compared to headache and control groups.
    • Patients with tension-type headache showed a distinct postimperative negative wave pattern.

    Impact:

    • CND may serve as a valuable objective biomarker for diagnosing migraine in children.
    • This research contributes to the neurophysiological understanding of pediatric headache disorders.
    • Findings could lead to improved diagnostic tools and earlier intervention for childhood migraine.

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