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[Immune status in children with psychomotor development disturbances]

I V Shcherbakova, L G Khachatrian, S A Krasnolobova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |July 23, 2003
    PubMed

    Insights

    Leukocyte elastase (LE) activity and nerve growth factor (NGF) autoantibodies are linked to psychomotor disturbances in children. Elevated LE and NGF autoantibodies suggest immune system involvement in these developmental issues.

    Area of Science:

    • Immunology
    • Neuroscience
    • Developmental Pediatrics

    Context:

    • Psychomotor development disturbances in children can stem from cerebral organic causes, including perinatal encephalopathy.
    • Assessing innate and adaptive immunity provides insights into the pathophysiology of these conditions.

    Purpose:

    • To investigate the role of leukocyte elastase (LE) activity and autoantibodies to nerve growth factor (NGF) in children with psychomotor development disturbances of cerebral organic origin.
    • To explore correlations between these immunological markers and clinical symptoms.

    Summary:

    • Leukocyte elastase (LE) activity was found to be elevated in children with mild to moderate psychomotor disturbances linked to perinatal encephalopathy.
    • Higher LE activity correlated significantly with increased titers of autoantibodies to nerve growth factor (NGF) in children with cerebral organic psychomotor disturbances.
    • The study identified correlations between specific immunological parameters and clinical manifestations.

    Impact:

    • The findings suggest that both innate and adaptive immune system components are implicated in the pathophysiology of psychomotor development disturbances in children.
    • This research highlights potential immunological biomarkers for understanding and potentially managing these developmental disorders.

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