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Related Experiment Videos

Specific immunotherapy for severe latex allergy.

C Pereira1, E Pedro, B Tavares

  • 1Immunoallergology Department, Coimbra University Hospital, Coimbra, Portugal.

European Annals of Allergy and Clinical Immunology
|July 23, 2003
PubMed
Summary

Specific immunotherapy (SIT) effectively treated latex allergy in four patients with anaphylaxis and oral-latex-fruit syndrome. SIT demonstrated safety and efficacy, reducing symptoms and skin reactivity in patients.

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Latex allergy can cause severe anaphylaxis and is often associated with oral-latex-fruit syndrome.
  • Occupational exposure and surgical needs present significant challenges for individuals with latex allergy.

Observation:

  • Four patients (3 adult females, 1 boy) with confirmed latex sensitization (positive SPT, elevated IgE) were treated with subcutaneous specific immunotherapy (SIT).
  • A modified rush schedule was used, establishing a maintenance dose (MD) of 0.35 μg protein, with one patient experiencing a transient systemic reaction at a higher dose.
  • Patients were monitored for symptom resolution, particularly in workplace settings and during surgical procedures.

Findings:

  • Following SIT, all three female patients remained asymptomatic in the workplace, and two showed no symptoms upon latex glove challenge, with one experiencing mild rhinoconjunctivitis.

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  • The boy with spina bifida underwent a surgical intervention without any allergic reaction after completing SIT.
  • A reduction in latex skin reactivity was observed in all treated patients.

    • Implications:

    • Specific immunotherapy (SIT) with a latex aqueous extract is a safe and effective treatment for patients with severe latex allergy.
    • SIT can significantly improve quality of life and reduce allergic reactions in occupational and clinical settings.
    • The established maintenance dose and administration schedule appear well-tolerated and effective in managing latex allergy.