Related Experiment Video
Updated: Jul 31, 2026
A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
Published on: July 5, 2017
Tear function tests and conjunctival impression cytology before and after hormone replacement therapy in
A Pelit1, T Bağiş, F Kayaselçuk
1Başkent Univ. Faculty of Medicine, Dept. of Ophthalmology, Adana Teaching and Medical Research Center, Ankara, Turkey. apelit@cu.edu.tr
Purpose:
To investigate the effect of hormone replacement therapy (HRT) on postmenopausal tear function and the conjunctival epithelium.
Methods:
Schirmer I-Jones test, tear film break-up time (BUT), and impression cytology findings were analyzed in 34 eyes of 17 women who were at least two years postmenopausal and not taking HRT: This series of tests was repeated after three months on HRT.
Results:
The patients' average age was 53.82 +/- 3.6 years, and the mean time postmenopause was 35.29 +/- 11.59 months. There was no significant difference in the Schirmer I-Jones test results before and after three months of HRT (p > 0.05). However, the BUT (p < 0.05) and impression cytology (p < 0.05) findings were significantly affected by HRT.
Conclusions:
HRT may alleviate postmenopausal dry eye symptoms by increasing goblet cell density.
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