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[Increased fibrinogen and factor VII activity levels in patients after myocardial infarction]
Insights
Patients with myocardial infarction show higher fibrinogen and factor VII activity. These factors correlate positively with cholesterol and triglycerides, suggesting a role in clot formation and potential targets for prophylaxis.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Biochemistry
Background:
- Hemostatic system parameters in coronary heart disease (CHD) require further definition.
- Epidemiological studies link elevated fibrinogen levels to increased cardiovascular morbidity and mortality.
- Factor VII activation has a crucial role in clot formation within the coagulation cascade.
Purpose of the Study:
- To investigate fibrinogen levels and factor VII activity in patients with a history of myocardial infarction (MI).
- To explore correlations between fibrinogen, factor VII activity, and other biochemical markers in CHD patients.
Main Methods:
- Studied 22 male patients under 55 with MI history and 22 healthy male controls.
- Measured plasma fibrinogen (F) levels and factor VII activity (fVIIa).
- Analyzed correlations between fVIIa, F, serum cholesterol, and triglycerides.
Main Results:
- Patients with MI history exhibited elevated mean fibrinogen (363.3 mg/dl) and factor VIIa (150.3%) levels.
- A significant positive correlation was observed between fVIIa and F level (r=0.62).
- fVIIa also showed positive correlations with serum cholesterol (r=0.35) and triglycerides (r=0.32).
Conclusions:
- Elevated fibrinogen and factor VIIa are associated with myocardial infarction.
- Factor VIIa levels correlate with key lipid parameters, suggesting a complex interplay in thrombogenesis.
- Dietary influences on fVIIa warrant further investigation.
- Oral anticoagulants may be beneficial for myocardial infarction prophylaxis.
Abstract:
Functional and biochemical parameters of the haemostatic system in coronary heart disease (CHD) are still not well defined. Epidemiological studies indicate a positive correlation between fibrinogen (F) level and cardiovascular morbidity and mortality. Two independent ways of factor VII activation in the coagulation cascade suggest a special role of this factor in clot forming (Fig. 1). 22 patients (pts) under 55 yrs with a history of myocardial infarction (MT) and 22 healthy control men were studied for F level and factor VII activity (fVIIa). We found increased F level (M-363.3 mg/dl) and high level of VIIa (M-150.3%) in plasma of pts with a history of MI. Furthermore a strong positive correlation between fVIIa in plasma and F level (r = 0.62), serum cholesterol (chol) (r = 0.35), serum triglycerides (tg) (r = 0.32) (Tab. 2) was bound. Calculations were performed for all subjects: pts and control combined in one group. A possible influence of diet on fVIIa level is discussed. One should consider the usefulness of oral anticoagulants in the prophylaxis of MT.