p-Terphenyls from the basidiomycete Thelephora aurantiotincta

Area of Science:

• Natural Product Chemistry
• Mycology
• Organic Chemistry

Background:

• Thelephora aurantiotincta is a species of fungus known to produce bioactive compounds.
• P-terphenyls are a class of organic compounds with diverse biological activities.

Purpose of the Study:

• To isolate and characterize novel compounds from the fruiting bodies of Thelephora aurantiotincta.
• To elucidate the structures of isolated compounds using comprehensive spectroscopic and chemical techniques.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation via Mass Spectrometry (MS), Infrared (IR), Ultraviolet (UV) spectroscopy, and Nuclear Magnetic Resonance (NMR) including H-H COSY, HMQC, and HMBC experiments.
• Confirmation of structures through chemical methods.

Main Results:

• A new p-terphenyl, aurantiotinin A (1), was isolated and identified.
• Two known compounds, ganbajunin C (2) and atromentin (3), were also isolated from the same fungal source.
• The structures of all three compounds were definitively established.

Conclusions:

• The chemical investigation of Thelephora aurantiotincta yielded a novel p-terphenyl and two known compounds.
• Aurantiotinin A represents a new addition to the known p-terphenyl family.
• The study contributes to the understanding of the chemical diversity within the Thelephora genus.