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Mitomycin C-induced renal insufficiency: a case report.

Mei-Chin Wen1, Cheng-Hsu Chen, William L Ho

  • 1Department of Pathology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. mewen@vghtc.vghtc.gov.tw

The Kaohsiung Journal of Medical Sciences
|July 23, 2003
PubMed
Summary

Mitomycin C (MMC) chemotherapy can cause kidney damage, including thrombotic microangiopathy, leading to hypertension and renal insufficiency. Close monitoring of blood pressure and kidney function is crucial for patients undergoing MMC treatment.

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Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Gastric cancer management often involves adjuvant chemotherapy.
  • Mitomycin C (MMC) is an alkylating agent used in chemotherapy regimens.

Observation:

  • A 58-year-old male developed anemia, hypertension, and renal impairment during MMC treatment for gastric cancer.
  • Kidney biopsy revealed thrombotic microangiopathy with mesangiolysis and tubular cell atypia.

Findings:

  • Chemotherapy-induced thrombotic microangiopathy (TMA) presented as hypertension and renal insufficiency.
  • Histopathology confirmed TMA with specific glomerular and tubular changes.
  • Treatment with plasma exchange, antihypertensives, and antiplatelets stabilized renal function.

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Implications:

  • Patients receiving Mitomycin C require vigilant monitoring for adverse renal effects.
  • Early detection and management of MMC-induced nephrotoxicity are essential.
  • This case highlights the potential for severe renal complications from adjuvant chemotherapy.