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Updated: Sep 22, 2026

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
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Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

Published on: December 30, 2025

Intracranial sinus thrombosis in a patient with Crohn disease and factor V Leiden mutation

Jennifer Maag1, Richard A Prayson

  • 1Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Archives of Pathology & Laboratory Medicine
|July 23, 2003
PubMed

There is a well-known risk of thrombosis in patients with inflammatory bowel disease. Documented cases of intracranial sinus thrombosis in this setting are rare. We present the case of a 30-year-old man with Crohn disease who spontaneously developed a superior sagittal sinus thrombosis and bifrontal infarcts that resulted in death. The patient was heterozygous for factor V Leiden mutation. The literature was searched to assess the frequency of cerebral venous infarcts in inflammatory bowel disease and the role that factor V Leiden plays in thrombosis in such patients.

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