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Modafinil treatment of opioid-induced sedation
Lynn Webster1, Megan Andrews, Gregory Stoddard
1Alpine Pain and Addiction Medicine, Salt Lake City, Utah 84107, USA. lynnw@alpinemedical.com
Study Objective:
The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.
Design:
A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS).
Setting:
Outpatient, private practice.
Patients:
Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain.
Results:
A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment.
Conclusion:
The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.
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