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Hypocholesterolemic activity of hesperetin derivatives
Tae-Sook Jeong1, Eun Eai Kim, Chul-Ho Lee
1Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Taejon 305-333, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|July 23, 2003
Abstract:
Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.