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Structure--activity relationships of azasugar-based MMP/ADAM inhibitors
Hideki Moriyama1, Takahiro Tsukida, Yoshimasa Inoue
1Japan Bioindustry Association, Hokkaido Collaboration Center, N-21, W-12, Kita-Ku, Sapporo 001-0021 Japan.
Bioorganic & Medicinal Chemistry Letters
|July 23, 2003
Abstract:
In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.