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Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity
Paola Barraja1, Patrizia Diana, Antonino Lauria
1Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy.
Bioorganic & Medicinal Chemistry Letters
|July 23, 2003
Abstract:
A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.