Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Marker seed migration in prostate localization.

Matthew M Poggi1, Dean A Gant, Wilfred Sewchand

  • 1Radiation Oncology Service, Department of Radiology, Walter Reed Army Medical Center, Washington, DC, USA. mpoggi@usuhs.mil

International Journal of Radiation Oncology, Biology, Physics
|July 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ACR Appropriateness Criteria®-Recurrent Rectal Cancer.

Gastrointestinal cancer research : GCR·2012
Same author

ACR Appropriateness Criteria: local excision in early-stage rectal cancer.

Current problems in cancer·2010
Same author

ACR Appropriateness Criteria: rectal cancer-metastatic disease at presentation.

Current problems in cancer·2010
Same author

ACR Appropriateness Criteria on resectable rectal cancer: expert panel on radiation oncology--rectal/anal cancer.

International journal of radiation oncology, biology, physics·2008
Same author

The design and implementation of a multidisciplinary prostate cancer clinic.

Urologic nursing·2008
Same author

Prostate cancer metastatic to the external auditory canals.

Clinical genitourinary cancer·2007
Same journal

Single Percussive Ventilation Breath-hold Imaging and Delivery in Lung Tumor Stereotactic Ablative Radiation Therapy: Initial Observations From a Prospective Clinical Trial.

International journal of radiation oncology, biology, physics·2026
Same journal

Proton beam therapy in nonmetastatic rhabdomyosarcoma: Outcome, prognostic factors and the effect of timing of radiation therapy.

International journal of radiation oncology, biology, physics·2026
Same journal

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

International journal of radiation oncology, biology, physics·2026
Same journal

Gastrointestinal Motility-Induced Interplay in Pancreas Proton Therapy: Motion Simulation and Dosimetric Impact.

International journal of radiation oncology, biology, physics·2026
Same journal

Intra-fractional Voxel-wise Anatomical Motion Tracking Guided by Multimodal Respiratory Surrogates in Radiotherapy: Framework Development and Multi-Center Validation.

International journal of radiation oncology, biology, physics·2026
Same journal

A Gaussian-based planning approach for robust dose-escalated stereotactic body proton therapy.

International journal of radiation oncology, biology, physics·2026
See all related articles

Prostate marker seeds show negligible migration during radiotherapy, confirming their reliability for tracking gland location. Minor individual seed movements occur but do not compromise accuracy for external beam radiation therapy.

Area of Science:

  • Oncology
  • Medical Physics
  • Radiotherapy

Background:

  • Implanted seeds (fiducial markers) are increasingly used for prostate gland localization in radiotherapy.
  • Data evaluating the validity of marker seed localization, especially throughout external beam radiation therapy, is limited.

Purpose of the Study:

  • To analyze marker seed location and test the hypothesis of no intraseed migration within the prostate.
  • To assess the reliability of marker seeds as surrogates for prostate gland location during radiotherapy.

Main Methods:

  • Nine early-stage prostate cancer patients received 4-5 porous gold marker seeds (1.2 x 2.0 mm) implanted under ultrasound guidance.
  • Seed locations were digitized from weekly orthogonal radiographs using a CMS Focus planning system to determine intraseed spacing.

Related Experiment Videos

  • Digitizing error was assessed using the isocenter and other anatomical landmarks.

    • Main Results:

    • Average overall seed migration was 1.2 ± 0.2 mm over a 7-week radiotherapy course.
    • The maximum average seed movement in any patient was 1.9 mm; minimum average movement was 0.6 mm.
    • The greatest change in intraseed spacing observed was 6.6 mm; digitizing error was 0.20 ± 0.03 mm.

    Conclusions:

    • Marker seeds demonstrate negligible migration within the prostate during definitive radiotherapy.
    • Small, detectable movements in individual seeds may occur due to anatomical or treatment-related changes.
    • Prostate marker seeds are accurate and reliable surrogates for gland location throughout radiotherapy.