Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.

Erin E McClelland1, Donald L Granger, Wayne K Potts

  • 1Biology Department, University of Utah, Salt Lake City, Utah 84112, USA. Erin.McClelland@m.cc.utah.edu

Infection and Immunity
|July 23, 2003
PubMed
Summary

Major histocompatibility complex (MHC) genes significantly influence susceptibility to Cryptococcus neoformans infections in mice. This research demonstrates MHC genes play a crucial role in host resistance to this fungal pathogen.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Host genotype and sex shape influenza evolution and defective viral genomes.

Nature communications·2026
Same author

Intracellular <i>C. neoformans</i> infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages.

bioRxiv : the preprint server for biology·2025
Same author

Host genotype and sex shape influenza evolution and defective viral genomes.

Research square·2025
Same author

Host genotype and sex shape influenza evolution and defective viral genomes.

bioRxiv : the preprint server for biology·2025
Same author

A New Overview of Sex Bias in Fungal Infections.

Journal of fungi (Basel, Switzerland)·2024
Same author

Longitudinal associations of plasma amino acid levels with recovery from malarial coma.

Malaria journal·2024

Area of Science:

  • Immunogenetics
  • Microbial Pathogenesis
  • Host-Pathogen Interactions

Background:

  • Cryptococcus neoformans is an opportunistic fungal pathogen causing life-threatening infections.
  • The genetic factors, particularly host immune genes, underlying resistance to C. neoformans are not fully understood.

Purpose of the Study:

  • To investigate the role of major histocompatibility complex (MHC) genes in determining host susceptibility to Cryptococcus neoformans infection.
  • To establish an experimental model for studying MHC-dependent immune responses to fungal infections.

Main Methods:

  • Infection experiments were performed using genetically diverse MHC-congenic mouse strains.
  • Susceptibility to C. neoformans infection was assessed in different MHC homozygous and heterozygous mouse genotypes.

Related Experiment Videos

Main Results:

  • Significant differences in susceptibility to C. neoformans infection were observed among the MHC-congenic mouse strains.
  • Both homozygous and heterozygous genotypes exhibited varying degrees of resistance or susceptibility.

Conclusions:

  • Major histocompatibility complex (MHC) genes are critical determinants of host resistance to Cryptococcus neoformans.
  • This study provides the first experimental evidence of MHC-dependent susceptibility to C. neoformans in a murine model, highlighting the importance of MHC in antifungal immunity.