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Updated: Aug 14, 2026

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
Published on: April 20, 2017
[New regulatory peptides in rat stomach secretion (amylin, PGP, semax)]
1Moscow Lomonosov State University, Pavlov Institute of Physiology, Saint-Petersburg.
Abstract:
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate. The intraperitoneal introduction of these peptides in the doses that proved to have an apparent anti-ulcer effect caused a decrease of both basal production of hydrochloric acid in the stomach and production caused by the irritation of the vagus nerve. Semax and amylin also decreased basal and stimulated secretion of pepsinogen. Amylin and PGP did not have any effect on basal bicarbonate secretion of the stomach, and semax caused its short-time increase 35 minutes after the introduction. We made a conclusion that the decrease of aggressive factors in gastric juices can be a mechanism of the anti-ulcer action of all three peptides under study.
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