[Lactose tolerance in children with chronic gastroduodenal zone diseases]

We determined the dependence of the frequency of lactose intolerance, particular features of the clinical presentation and laboratory showings on lactase deficiency on the basis of a complex clinical, anamnestic and laboratory study of 149 children with chronic gastroduodenal pathologies. It was established that the prevalence of lactose intolerance in children with superficial gastroduodenitis amounts to 58.8%, in children with erosive gastroduodenitis--66.7% and in children with stomach ulcers--83.3%. During the oral lactose load and a subsequent laboratory study we revealed an impairment of the hydrolytic function of small intestines accompanied by an increase of fecal excretion of carbohydrates (lactose and monosaccharides) as well as a considerable enhancement of bacterial fermentation. The detection of fecal excretion of the total glycoprotein hexoses characterizes a disorder of the morphofunctional state of the gastrointestinal tract in children with intestinal enzymopathies.