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Related Experiment Videos

Fluorescence-based fibre optic arrays: a universal platform for sensing.

Jason R Epstein1, David R Walt

  • 1Max Tishler Laboratory for Organic Chemistry, Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.

Chemical Society Reviews
|July 24, 2003
PubMed
Summary

Optical fibres offer a versatile sensing platform for diverse applications, from simple pH sensors to complex cell arrays. Their high-density imaging bundles enable precise, rapid measurements and combined imaging with sensing capabilities.

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Area of Science:

  • Photonics and Sensor Technology
  • Biomedical Engineering
  • Materials Science

Background:

  • Optical fibres serve as a universal sensing platform, adaptable to various sensing schemes.
  • Imaging fibre bundles, composed of thousands of fused optical fibres, enable parallel sensing.
  • These bundles offer high-density sensor packing and combined imaging and sensing capabilities.

Purpose of the Study:

  • To review the versatility and applications of optical fibre-based sensing platforms.
  • To highlight the advantages of imaging fibre bundles for high-density, parallel sensing.
  • To discuss the integration of diverse sensing schemes with optical fibre technology.

Main Methods:

  • Utilizing imaging fibre bundles with miniature feature sizes (3-10 micron diameter fibres).

Related Experiment Videos

  • Implementing selective etching of fibre cores to create high-density microwell arrays.
  • Integrating various sensing schemes, including pH sensors, artificial olfaction, and oligonucleotide arrays.

    • Main Results:

    • Achieved high-density sensor packing (approx. 2 x 10(7) sensors/cm2).
    • Enabled combined imaging and sensing by transmitting coherent images.
    • Demonstrated faster response times and enhanced sensitivity due to miniature feature sizes.
    • Showcased the platform's versatility for single analyte monitoring and complex multiplexed assays.

    Conclusions:

    • Optical fibre imaging bundles provide a powerful, versatile platform for high-density, parallel sensing.
    • The technology facilitates tailored sensing designs for diverse experimental needs.
    • Miniature fibre sizes enhance measurement speed and sensitivity, opening new avenues in sensing applications.