Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pain information pathways from the periphery to the cerebral cortex].

Ryotaro Kuroda1, Atsufumi Kawabata

  • 1Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan. r_kuroda@phar.kindai.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|July 24, 2003
PubMed
Summary

Pain signals travel from the periphery to brain regions like the somatosensory cortex and anterior cingulate cortex. Protease-activated receptors 1 and 2 (PAR-1, PAR-2) show potential for novel pain drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Involvement of cystathionine β-synthase in ATP-induced hydrogen sulfide production in cochlear outer hair cells.

Journal of otology·2026
Same author

Involvement of Ca<sub>v</sub>3.2 T-Type Ca<sup>2+</sup> Channels and the Role of Endogenous Estrogen in Pruritus: Evidence from a Fundamental Study and Cross-Sectional Analysis of Pharmacy Claims Data.

Biological & pharmaceutical bulletin·2026
Same author

[Preface].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same author

[Chemotherapy-induced peripheral neuropathy and sex hormones].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same author

[Effectiveness of Angiotensin System Inhibitors Against Painful Peripheral Neuropathy in Type 2 Diabetic Old Patients: Validation by Analysis of Pharmacy Claims Data].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2025
Same author

Identification of potentially inappropriate medications characteristic of older individuals with diabetes: a study using pharmacy claims data.

Journal of pharmaceutical health care and sciences·2025

Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Context:

  • Pain perception involves complex ascending pathways to multiple cerebral cortices.
  • Clinical pain integrates sensory-discriminative and affective-cognitive dimensions.
  • Positron Emission Tomography (PET) studies reveal brain activation patterns during painful stimulation.

Purpose:

  • To elucidate the ascending pain pathways from the periphery to the somatosensory cortices (SI, SII) and anterior cingulate cortex.
  • To investigate the roles of protease-activated receptors 1 (PAR-1) and 2 (PAR-2) in pain signaling.
  • To explore the potential of PAR-1 and PAR-2 as therapeutic targets for pain management.

Summary:

  • Painful peripheral stimulation activates the first and second somatosensory cortices (SI, SII) and anterior cingulate cortex.

Related Experiment Videos

  • SI and SII are implicated in the somatosensory-discriminative aspects of pain, while the anterior cingulate cortex processes the affective-cognitive aspects.
  • Protease-activated receptor 2 (PAR-2) activation is pronociceptive, whereas PAR-1 activation appears antinociceptive, suggesting distinct roles in pain modulation.

    • Impact:

    • Identifies specific cortical regions involved in different pain dimensions.
    • Highlights the opposing roles of PAR-1 and PAR-2 in nociception.
    • Provides a foundation for developing novel analgesics targeting PAR-1 and PAR-2 pathways.