Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomic instability and radiation.

John B Little1

  • 1Harvard School of Public Health, Boston, MA 02115, USA. jlittle@hsph.harvard.edu

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
|July 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The MDM2/MDMX/p53 axis in the adaptive stress response.

Translational cancer research·2022
Same author

MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment.

Journal of molecular cell biology·2020
Same author

Response to the Letter by Colin Seymour and Carmel Mothersill.

Radiation research·2020
Same author

Functional interplay between p53 and Δ133p53 in adaptive stress response.

Cell death and differentiation·2019
Same author

MDMX under stress: the MDMX-MDM2 complex as stress signals hub.

Translational cancer research·2018
Same author

ZBTB7A governs estrogen receptor alpha expression in breast cancer.

Journal of molecular cell biology·2018
Same journal

OBITUARYRoger Clarke 1943-2026.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

Radiation protection knowledge among healthcare professionals and students - what (if anything) are studies telling us?

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

Impact of the ICRU/ICRP proposal on operational quantities during interventional procedures: Investigation through spectral measurements.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

The Declaration of Adelaide White paper: Guidelines for Author Responsibility in Peer Review.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

Assessment of the extremity exposure during preparation and administration of 177Lu - results of a multi-center study.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

Stochastic Expansion of Radionuclide Inhalation Dosimetry for Consequence Management Application: Uncertainty and Sensitivity Analysis in the ICRP 130 Human Respiratory Tract Model.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
See all related articles

Ionizing radiation can induce genomic instability in normal cells, increasing mutation rates across generations. This instability may drive cancer development by accelerating the accumulation of necessary genetic changes.

Area of Science:

  • Genetics
  • Cancer Biology
  • Radiation Biology

Background:

  • Genomic instability is a key characteristic of cancer cells and is implicated in carcinogenesis.
  • Rare genetic disorders predispose individuals to cancer due to genomic instability in somatic cells.

Purpose of the Study:

  • To review experimental evidence on radiation-induced transmissible genomic instability.
  • To explore the role of induced instability in radiation carcinogenesis and cancer progression.

Main Methods:

  • Review of experimental data on radiation-induced genomic instability.
  • Analysis of mutation and chromosomal aberration rates in irradiated cell progeny.
  • Investigation of transmissible instability in somatic cells.

Related Experiment Videos

Main Results:

  • Ionizing radiation can induce a persistent, transmissible genomic instability in normal somatic cells.
  • This induced instability enhances mutation and chromosomal aberration rates over many cell generations.
  • The findings suggest radiation may initiate cancer by promoting instability rather than solely through rare mutations.

Conclusions:

  • Radiation-induced genomic instability may be a significant factor in cancer development and progression.
  • Instability could facilitate the accumulation of multiple genetic events required for malignancy.
  • Further research is needed to fully elucidate the mechanisms and implications of radiation-induced genomic instability.