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Related Experiment Videos

The vertical linear vestibulo-ocular reflex in patients with a hyperactive response during horizontal angular

Frank Schmäl1, Rudolf Kunz, Wolfgang Stoll

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Münster, Germany. schmael.hno@uni-muenster.de

Acta Oto-Laryngologica
|July 24, 2003
PubMed
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Patients with a hyperactive angular vestibulo-ocular reflex (AVOR) also exhibit hyperactivity of the linear VOR (LVOR). This suggests a central vestibular system cause, not a peripheral one, for these observed reflex abnormalities.

Area of Science:

  • Vestibular Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Some patients exhibit bilateral hyperactive angular vestibulo-ocular reflex (AVOR) in clinical settings.
  • The relationship between hyperactive AVOR and linear vestibulo-ocular reflex (LVOR) hyperactivity is not well understood.

Purpose of the Study:

  • To investigate whether patients with hyperactive AVOR also demonstrate hyperactivity of the LVOR.
  • To explore the underlying cause of combined AVOR and LVOR hyperactivity.

Main Methods:

  • Prospective study involving 10 patients with hyperactive AVOR and 10 healthy controls.
  • Assessment of AVOR and vertical LVOR using rotational and linear acceleration tests in darkness and with visual stimulation.
  • Evaluation of smooth pursuit eye movements.

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Main Results:

  • Patients with hyperactive AVOR showed significantly higher mean eye velocities for both AVOR and vertical LVOR compared to controls.
  • Significant positive correlation found between AVOR and LVOR eye velocities across all subjects.
  • No significant differences in vertical smooth pursuit between patients and controls.

Conclusions:

  • Hyperactivity of the LVOR is present in patients with a hyperactive AVOR.
  • The involvement of distinct sensory organs and neural pathways points to a central vestibular lesion as the likely cause.
  • Findings suggest a central origin for these vestibular reflex abnormalities.