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Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields
Sabine Ivancsits1, Elisabeth Diem, Oswald Jahn
1Division of Occupational Medicine, University of Vienna, University Hospital/AKH, Waehringer Guertel 18-20, A-1090 Vienna, Austria. sabine.ivancsits@akh-wien.ac.at
Abstract:
Several studies indicating a decline of DNA repair efficiency with age raise the question, if senescence per se leads to a higher susceptibility to DNA damage upon environmental exposures. Cultured fibroblasts of six healthy donors of different age exposed to intermittent ELF-EMF (50 Hz sinus, 1 mT) for 1-24 h exhibited different basal DNA strand break levels correlating with age. The cells revealed a maximum response at 15-19 h of exposure. This response was clearly more pronounced in cells from older donors, which could point to an age-related decrease of DNA repair efficiency of ELF-EMF induced DNA strand breaks.