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Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part
R Jasztold-Howorko1, Z Machoń, M Wilimowski
1Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Polish Journal of Pharmacology and Pharmacy
|July 1, 1992
Abstract:
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-20 were synthesized and evaluated for their pharmacological activity. Compounds 11-14, 17-19 showed antiaggressive effect, compounds 5, 8, 9, 11, 12 and 19 displayed antiserotonin activity while compound 14 exerted antireserpine action.