Related Experiment Videos
Invasive pneumococcal disease in Oxford, 1985-2001: a retrospective case series.
C C Grant1, A R Harnden, G Jewell
1Department of Paediatrics, University of Auckland, New Zealand. cc.grant@auckland.ac.nz
Archives of Disease in Childhood
|July 24, 2003
Summary
Children with invasive pneumococcal disease (IPD) face higher risks linked to social deprivation and specific congenital conditions. These include central nervous system malformations, heart defects, and chromosomal abnormalities, highlighting key risk factors.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Invasive pneumococcal disease (IPD) remains a significant pediatric health concern.
- Understanding risk factors is crucial for targeted prevention and management strategies.
Purpose of the Study:
- To characterize the clinical features and identify risk factors for invasive pneumococcal disease (IPD) in a pediatric population.
- To assess the association between social deprivation and congenital abnormalities with IPD risk.
Main Methods:
- Retrospective review of pediatric patient records (0-18 years) with IPD diagnosed between 1985 and 2001.
- Utilized the Jarman index to quantify social deprivation.
- Compared the prevalence of congenital abnormalities with national data.
Main Results:
- 136 children with IPD were analyzed; median age at diagnosis was 1.5 years.
- Children with IPD came from more socially deprived households (p < 0.001).
- Significant IPD risk increases were observed for central nervous system malformations (OR=99), congenital heart disease (OR=62), and chromosomal abnormalities (OR=32).
Conclusions:
- Increased social deprivation is associated with a higher risk of invasive pneumococcal disease (IPD) in children.
- Specific congenital conditions, including CNS malformations, congenital heart disease, and chromosomal abnormalities, significantly elevate IPD risk.