Related Experiment Video

Updated: Sep 10, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Increased endogenous endothelin-1 in coronary circulation is associated with restenosis after coronary angioplasty

Hiroyuki Takase1, Masaya Sugiyama, Ai Nakazawa

  • 1Enshu General Hospital, Hamamatsu, Japan. h_takase@ken.ja-shizouka.or.jp

The Canadian Journal of Cardiology
|July 24, 2003
PubMed

Insights

Elevated endothelin-1 levels after percutaneous transluminal coronary angioplasty (PTCA) may signal an increased risk of coronary restenosis. This study investigated vasoactive substances as potential markers for restenosis post-PTCA.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biomarker Discovery

Background:

  • The role of vasoactive substances in coronary restenosis following percutaneous transluminal coronary angioplasty (PTCA) remains unclear.
  • Investigating potential biomarkers is crucial for managing post-procedural complications.

Purpose of the Study:

  • To ascertain if specific vasoactive substances can serve as indicators of coronary restenosis after PTCA.
  • To analyze the association between endothelin-1, nitric oxide, serotonin, angiotensin II, and noradrenaline with restenosis.

Main Methods:

  • Twenty-nine patients with angina pectoris underwent elective PTCA.
  • Coronary angiography assessed lesion patency three months post-PTCA.
  • Blood samples from the coronary sinus were collected before, immediately after, and three months after PTCA.

Main Results:

  • Endothelin-1 levels were significantly higher immediately after and three months post-PTCA in the restenosis group compared to baseline.
  • Nitrite/nitrate levels transiently decreased post-PTCA in both groups.
  • Serotonin levels decreased in the patency group but not in the restenosis group; angiotensin II and noradrenaline showed no significant changes.

Conclusions:

  • Endothelin-1 emerges as a potential marker associated with coronary restenosis after PTCA.
  • Elevated endothelin-1 in coronary circulation post-PTCA may predict a higher risk of restenosis.
Abstract

More Related Videos

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery09:41

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery

Published on: December 23, 2014

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...