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New building blocks for the assembly of sequence selective molecular zippers
Christopher A Hunter1, Philip S Jones, Pascale M N Tiger
1Centre for Chemical Biology, Krebs Institute for Biomolecular Science, Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF.
Chemical Communications (Cambridge, England)
|July 25, 2003
Abstract:
Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new orthogonal recognition motif and the mutually complementary binding partners form complexes an order of magnitude more stable than the corresponding mismatch complexes.