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Antioxidative constituents from Buddleia officinalis.

Mei Shan Piao1, Mi-Ran Kim, Dong Gun Lee

  • 1College of Pharmacy, Chosun University, Gwangju 501-759, Korea.

Archives of Pharmacal Research
|July 25, 2003
PubMed
Summary

Compounds from Buddleja officinalis flowers show antioxidant and antifungal properties. Luteolin and acteoside demonstrated the strongest antioxidant effects in NBT superoxide scavenging assays.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Buddleja officinalis, a traditional medicinal plant, contains various bioactive compounds.
  • Flavonoids, phenylethyl glycosides, and phenylpropanoid glycosides are classes of natural products with diverse biological activities.
  • Understanding the chemical constituents and bioactivities of B. officinalis flowers is important for potential therapeutic applications.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the flowers of Buddleja officinalis.
  • To evaluate the antioxidative, antifungal, and hemolytic activities of the isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through comprehensive spectroscopic analysis (e.g., NMR, MS).

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  • Assessment of antioxidative activity using the NBT superoxide scavenging assay.
  • Evaluation of antifungal activity against relevant fungal strains.
  • Determination of hemolytic activity on red blood cells.

    • Main Results:

    • Four flavonoids (1-4), one phenylethyl glycoside (5), and one phenylpropanoid glycoside (6) were successfully isolated and identified.
    • Luteolin (1) and acteoside (6) exhibited significant antioxidative activity in the NBT assay.
    • All tested compounds (1-6) displayed weak antifungal activity.
    • None of the isolated compounds showed hemolytic activity.

    Conclusions:

    • The flowers of Buddleja officinalis are a rich source of bioactive flavonoids and glycosides.
    • Luteolin and acteoside are key compounds responsible for the antioxidative potential of B. officinalis flowers.
    • The isolated compounds possess mild antifungal properties and lack toxicity concerning hemolytic activity, suggesting further investigation for therapeutic development.