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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
[Percutaneous transluminal angioplasty and severe limb ischaemia]
R Gaillard1, B Alarcon, A Tinajero
1Clinique chirurgicale adulte Ouest, centre hospitalier régional universitaire de Lille, hôpital Claude-Huriez, 3e étage, aile ouest, 59037 cedex, Lille, France.
Objectives:
To determine the outcome and the place of transluminal angioplasty (ATL) in the treatment of severe limb ischaemia.
Materials And Methods:
Seventy two legs at stage III and IV of Fontaine's classification have been exclusively treated by endoluminal procedures. The success was valued both on the haemodynamic post-operative improvement of the run-off flow and on the clinical statut leading to the conservation at mid-term of a functional limb. Patency and survival rate had been valued by actuarial method.
Results:
Seventy percent of the limbs were haemodynamically improved. For the global population, a 48% clinical success rate was obtained at 6 months but 30.5% of limbs were loss. Primary patency rate was respectively 79, 71 and 68% at 6, 12 and 24 month. The quality of the run-off arteries has been the most influential factor.
Conclusion:
Endoluminal treatment of chronic limb ischaemia had lead to a clinical improvement in 48% of cases. Multi-stages and distal atherosclerotic disease of this patients limits ATL indications which results depend of run-off quality.
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