Pyrrolidine carbamate nucleic acids: synthesis and DNA binding studies

An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as nitrophenyl carbonates for the synthesis of dimer, trimer and oligomers.