Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues
Esther Caballero1, Marta Adeva, Suzanne Calderón
1Laboratorio de Qui;mica Orgánica y Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. escab@usal.es
Bioorganic & Medicinal Chemistry
|July 25, 2003
Abstract:
An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo[3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles.
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