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Circadian activity rhythms in high-alcohol-preferring and low-alcohol-preferring mice.

John R Hofstetter¹, Nicholas J Grahame, Aimee R Mayeda

¹Richard L. Roudebush VA Medical Center, and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA. jhofstet@iupui.edu

Alcohol (Fayetteville, N.Y.)

|July 25, 2003

Summary

High-alcohol-preferring mice exhibit shorter circadian periods compared to low-alcohol-preferring mice. This suggests shared genetic influences between alcohol preference and biological rhythms.

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Area of Science:

Chronobiology
Behavioral Genetics
Neuroscience

Background:

Circadian rhythms regulate physiological processes.
Genetic selection has created distinct alcohol-preferring mouse lines.
Understanding genetic links to alcohol consumption is crucial.

Purpose of the Study:

To compare circadian periods between high-alcohol-preferring (HAP) and low-alcohol-preferring (LAP) mice.
To investigate potential pleiotropic effects of genes related to alcohol preference on circadian rhythms.

Main Methods:

Comparison of circadian periods using running-wheel activity in constant darkness.
Assessment of daily wheel revolutions and body weights.
Utilized ethanol-naive HAP and LAP mice.

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Main Results:

HAP mice displayed significantly shorter circadian periods than LAP mice.
HAP mice showed a tendency for increased wheel-running activity.
Body weights did not show significant differences between lines.

Conclusions:

Genes influencing alcohol consumption in mice may also affect circadian period.
Pleiotropic effects of these genes could link alcohol preference and biological timing.
Further research is warranted to elucidate the specific genetic mechanisms.