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Related Experiment Videos

Design of controlled-release formulation for ivermectin using silicone.

H Maeda1, M Brandon, A Sano

  • 1Formulation research Laboratories, Sumitomo Pharmaceuticals Co. Ltd., 3-45 Kurakakiuchi 1-Chome, Ibaraki-shi, 567-0878, Osaka, Japan. maedah@sumitomopharm.co.jp

International Journal of Pharmaceutics
|July 25, 2003
PubMed
Summary

This study developed a silicone-based formulation for controlled, long-term ivermectin (IVM) release. Subcutaneous administration in mice showed sustained IVM blood levels for 3 months, with potential for year-long release.

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Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Science

Background:

  • Controlled drug delivery systems are crucial for maintaining therapeutic drug concentrations.
  • Ivermectin (IVM) is an antiparasitic drug with potential for extended-release applications.

Purpose of the Study:

  • To design and evaluate a silicone-based matrix formulation for sustained ivermectin release.
  • To investigate factors influencing the release kinetics of ivermectin from the formulation.

Main Methods:

  • Development of a cylindrical, silicone-based, matrix-type formulation containing ivermectin (IVM).
  • Modification of the formulation with additives like polyethylene glycol 4000 (PEG) and sodium desoxycholate.
  • In vitro release studies and subcutaneous administration in mice to assess in vivo drug concentration.

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Main Results:

  • The developed covered-rod (CR) formulation demonstrated linear ivermectin release.
  • Addition of PEG accelerated IVM release, while sodium desoxycholate enabled linear in vitro release for up to 1 year.
  • Subcutaneous administration in mice maintained IVM blood concentration within one order of magnitude for 3 months.

Conclusions:

  • Silicone-based formulations offer a viable strategy for achieving long-term, controlled release of ivermectin.
  • Formulation additives can modulate ivermectin release profiles, enabling tailored drug delivery durations.
  • The CR formulation shows promise for sustained ivermectin therapy with infrequent administration.