Related Experiment Video
Updated: Jul 27, 2026

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
Published on: June 27, 2014
Design of controlled-release formulation for ivermectin using silicone
1Formulation research Laboratories, Sumitomo Pharmaceuticals Co. Ltd., 3-45 Kurakakiuchi 1-Chome, Ibaraki-shi, 567-0878, Osaka, Japan. maedah@sumitomopharm.co.jp
Abstract:
The purpose of this study was to design a formulation using silicone as carrier, so that release of ivermectin (IVM) can be controlled for a long period of time. The lateral side of a cylindrical matrix-type formulation composed of IVM and silicone was covered with silicone to obtain a covered-rod (CR) formulation. With this formulation, linear release of IVM was obtained. With addition of polyethylene glycol 4000 (PEG), release of IVM was accelerated. In a trial with subcutaneous administration to mice, blood concentration of IVM was maintained within one-order over a period of 3 months. The velocity of release of IVM from CR preparation depended on the change in solubility of IVM by additives, and in the case of a formulation with addition of desoxycholate sodium, linear in vitro release of IVM was observed over a period of 1 year.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Rate-Programmed I
Oral Drug Delivery Systems: Delayed-Release Systems
Intrauterine Drug Delivery Systems

