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Diabetic heart dysfunction: is cell transplantation a potential therapy?
Joel Price1, Subodh Verma, Ren-Ke Li
1Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Toronto General Hospital, Toronto, Canada.
Insights
Diabetes mellitus causes serious end-organ complications, with cardiovascular disease being the most significant. Rising diabetes prevalence, driven by obesity and inactivity, increases cardiovascular disease risk in patients.
Area of Science:
- Endocrinology
- Cardiology
- Public Health
Background:
- Long-standing diabetes mellitus is associated with multiple end-organ complications.
- Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in diabetic patients, accounting for up to 85% of deaths.
- Increasing prevalence of obesity and sedentary lifestyles contributes to the rising incidence of diabetes.
Purpose of the Study:
- To highlight the significant impact of diabetes mellitus on cardiovascular health.
- To underscore the link between diabetes prevalence and cardiovascular disease incidence.
Main Methods:
- Epidemiological analysis of diabetes complications.
- Clinical review of cardiovascular disease in diabetic populations.
Main Results:
- Cardiovascular disease is the most critical complication of diabetes mellitus.
- Diabetes is an increasing cause of cardiovascular disease, particularly in Western societies.
- Lifestyle factors like obesity and inactivity are driving the increase in diabetes and subsequent CVD.
Conclusions:
- Diabetes mellitus poses a substantial threat to cardiovascular health.
- Effective management of diabetes and lifestyle modifications are crucial for reducing cardiovascular complications.
- Public health initiatives addressing obesity and sedentary behavior are essential to curb the growing burden of diabetes and CVD.
Abstract:
The presence of long-standing diabetes mellitus leads to the development of a number of typical end organ complications. These complications include coronary heart disease, stroke, peripheral arterial disease, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and diabetic cardiomyopathy. From an epidemiological and clinical standpoint, cardiovascular disease remains the most important complication of diabetes. Cardiovascular complications are the most common causes of morbidity and mortality in diabetics, accounting for up to 85% of the mortality in diabetic patients. The increasing prevalence of obesity and sedentary lifestyle in Western society are leading to an increase in the prevalence in diabetes. As such diabetes is an increasing cause of cardiovascular disease.