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Updated: May 8, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
11:28

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RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

Hironori Katoh1, Manabu Negishi

  • 1Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan. hirokato@pharm.kyoto-u.ac.jp

Nature
|July 25, 2003
PubMed
Summary

The small GTPase RhoG activates Rac1 through Elmo and Dock180, a pathway crucial for cell spreading and neurite outgrowth. This discovery clarifies how RhoG influences cell morphology and actin cytoskeleton regulation.

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