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Present and future of surface plasmon resonance biosensors
1Institute of Radio Engineering and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic. homola@ure.cas.cz
Analytical and Bioanalytical Chemistry
|July 25, 2003
Abstract:
Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.