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Updated: Sep 21, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic diterpenes from Scoparia dulcis
Monira Ahsan1, S K N Islam, Alexander I Gray
1Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh. monira@smpt.udhaka.net
Abstract:
Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.