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Related Experiment Videos

Risperidone-induced obsessive-compulsive symptoms in two children.

Rasim Somer Diler1, Aysegul Yolga, Ayse Avci

  • 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Cukurova University, Balcali, Adana, Turkey. dilerrs@yahoo.com

Journal of Child and Adolescent Psychopharmacology
|July 26, 2003
PubMed
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Two children developed rapid-onset obsessive-compulsive symptoms after starting risperidone (an atypical antipsychotic). Symptoms resolved upon medication discontinuation, suggesting a potential adverse effect in pediatric patients.

Area of Science:

  • Child and Adolescent Psychiatry
  • Pediatric Neurology
  • Pharmacology

Background:

  • Atypical antipsychotics, such as risperidone, are used to manage various behavioral and psychiatric conditions in children.
  • Obsessive-compulsive symptoms (OCS) and anxiety symptoms are complex conditions with multifactorial etiologies in pediatric populations.

Observation:

  • Two pediatric cases presented with sudden onset of obsessive-compulsive symptoms shortly after initiating risperidone treatment.
  • Case A: An 8-year-old boy with ADHD and tic disorder developed OCS within 2 weeks of risperidone initiation, which resolved upon discontinuation.
  • Case B: An 11-year-old girl with mild intellectual disability and aggression experienced sudden OCS emergence 10 days after starting risperidone, resolving within 3 days of cessation. Streptococcal pharyngitis was excluded in both cases.

Findings:

Related Experiment Videos

  • Risperidone treatment was temporally associated with the rapid emergence of obsessive-compulsive symptoms in both pediatric cases.
  • Discontinuation of risperidone led to the resolution of these symptoms, indicating a likely drug-induced effect.
  • The absence of streptococcal pharyngitis ruled out a common infectious trigger for PANDAS/PANS.

Implications:

  • These cases highlight a potential adverse effect of risperidone, specifically the induction of obsessive-compulsive symptoms in children.
  • Clinicians should maintain a high index of suspicion for drug-induced OCS when treating pediatric patients with atypical antipsychotics.
  • Further research is warranted to elucidate the mechanism underlying atypical antipsychotic-induced OCS in children and to inform clinical management strategies.