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Biodegradable microspheres for protein delivery.

V R Sinha1, Aman Trehan

  • 1Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, 160014 Chandigarh, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 26, 2003
PubMed
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Biodegradable microspheres offer a promising solution for controlled protein delivery, overcoming limitations of traditional methods. These systems protect sensitive proteins and enable sustained release, improving patient compliance and therapeutic outcomes.

Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Proteins face significant bioavailability challenges via oral, transdermal, ocular, and nasal routes due to size, degradation, and poor absorption.
  • Parenteral delivery is currently the most viable route for systemic protein administration.
  • Biodegradable microspheres have emerged as key parenteral depot formulations for protein delivery.

Purpose of the Study:

  • To review the advancements in biodegradable microspheres for controlled protein delivery.
  • To highlight the advantages of microsphere-based systems in overcoming protein delivery barriers.
  • To discuss preparation methods, release kinetics, stability, immunogenicity, and regulatory aspects.

Main Methods:

  • Literature review focusing on biodegradable microspheres for protein delivery.

Related Experiment Videos

  • Analysis of preparation techniques, characterization methods, and in vitro/in vivo performance.
  • Examination of protein stability, immune response, and regulatory pathways.

    • Main Results:

    • Biodegradable microspheres effectively protect proteins from degradation.
    • These systems allow for prolonged, modified, or pulsatile release profiles.
    • Microspheres enhance patient compliance by reducing the need for frequent injections.

    Conclusions:

    • Biodegradable microspheres represent a significant development in controlled protein injectables.
    • They offer a versatile platform for improving protein therapeutic efficacy and patient experience.
    • Further research and regulatory considerations are crucial for clinical translation.