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Structure formation in injectable poly(lactide-co-glycolide) depots.

Liwei Wang1, Lothar Kleiner, Subbu Venkatraman

  • 1School of Materials Engineering, Nanyang Technological University, N4.1-1-30 Nanyang Avenue, 639798 Singapore.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 26, 2003
PubMed
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Injectable poly(lactide-co-glycolide) (PLGA) drug depots show degradation and gelation in benzyl benzoate. Solvent choice impacts PLGA degradation and gelation, crucial for controlled drug delivery systems.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Injectable poly(lactide-co-glycolide) (PLGA) solutions are explored for sustained drug delivery.
  • Understanding PLGA behavior in organic solvents is key for developing effective drug depots.

Purpose of the Study:

  • To investigate structure formation in poly(lactide-co-glycolide)/benzyl benzoate systems.
  • To analyze the interplay between degradation and gelation in PLGA solutions.

Main Methods:

  • Controlled stress rheometry to assess flow properties and structure.
  • Gel permeation chromatography (GPC) to monitor molecular weight changes.
  • Differential scanning calorimetry (DSC) to detect thermal transitions like gelation.

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Main Results:

  • GPC confirmed PLGA molecular weight decrease over time and temperature, indicating degradation.
  • Rheology revealed that PLGA/benzyl benzoate solution properties are influenced by both degradation and gelation.
  • DSC detected an endotherm associated with gelation, further supported by rheological 3D structure studies.
  • The extent of PLGA degradation and gelation was found to be solvent-dependent.

Conclusions:

  • PLGA solutions in benzyl benzoate undergo both degradation and gelation, affecting their suitability as injectable drug depots.
  • Solvent properties significantly influence the degradation and gelation kinetics of PLGA.
  • These findings are critical for optimizing PLGA-based drug delivery systems for controlled release over weeks to months.