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Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype?

Debbie Scott1, Joanna Elsden, Andrew Pearson

  • 1Cancer Research Unit, University of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH UK.

Cancer Letters
|July 26, 2003
PubMed

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In-vitro Mutagenesis (Gene Knockouts)

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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