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Related Experiment Videos

Second-trimester pregnancy termination: comparison of three different methods.

A M Makhlouf1, T K Al-Hussaini, D M Habib

  • 1Department of Obstetrics and Gynecology, Assiut University Hospital, Egypt. makhloufsalama@yahoo.com

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|July 26, 2003
PubMed
Summary

Misoprostol offers effective second-trimester pregnancy termination with shorter intervals but more side effects. Dinoprostone is effective but costly. Glyceryl trinitrate aids cervical ripening but not contractions.

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Clinical Pharmacology

Background:

  • Second-trimester pregnancy termination requires effective and safe induction methods.
  • Prostaglandins like dinoprostone are commonly used, but alternatives are sought.
  • Cervical ripening is crucial for successful pregnancy termination.

Purpose of the Study:

  • To compare intravaginal misoprostol and dinoprostone for second-trimester pregnancy termination.
  • To evaluate glyceryl trinitrate as a nitric oxide donor for cervical ripening in this context.

Main Methods:

  • A randomized clinical trial involving pregnant women (13-28 weeks gestation) requiring termination.
  • Three groups received: vaginal misoprostol, vaginal dinoprostone, or vaginal glyceryl trinitrate.

Related Experiment Videos

  • Outcomes measured included complete abortion rate, induction-abortion interval, and side effects.

    • Main Results:

    • Misoprostol achieved 100% complete abortion rate with shorter induction-abortion intervals and fewer doses compared to dinoprostone.
    • Dinoprostone had a 66.67% complete abortion rate.
    • Glyceryl trinitrate alone showed 0% complete abortion but was effective for cervical ripening, achieving 100% with a complementary procedure.

    Conclusions:

    • Misoprostol is a cost-effective option for second-trimester termination, though associated with higher side effect rates.
    • Dinoprostone is effective but expensive and may require higher doses.
    • Glyceryl trinitrate is useful for cervical ripening but not for inducing uterine contractions in pregnancy termination.