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[Study for acid-base homeostasis in children with growth hormone deficiency]
You-jun Jiang1, Xiu-qin Chen, Li Liang
1The Affiliated Children' s Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China.
Insights
Children with growth hormone deficiency (GHD) have lower plasma actual bicarbonate levels and bicarbonate standard deviation scores (SDS) compared to those with idiopathic short stature (ISS). Bicarbonate SDS can help predict GHD in short children.
Area of Science:
- Pediatric Endocrinology
- Biochemistry
- Growth Disorders
Context:
- Short stature is a common concern in pediatric endocrinology.
- Distinguishing between growth hormone deficiency (GHD) and idiopathic short stature (ISS) is crucial for appropriate treatment.
- Biochemical markers may aid in the diagnostic process.
Purpose:
- To investigate differences in plasma actual bicarbonate concentrations between children with GHD and ISS.
- To evaluate the utility of plasma bicarbonate standard deviation scores (SDS) in diagnosing GHD.
Summary:
- This study compared plasma actual bicarbonate levels and SDS in 47 short children, divided into GHD and ISS groups.
- GHD patients exhibited significantly lower plasma actual bicarbonate concentrations and SDS compared to ISS patients.
- Anion gap was significantly higher in the GHD group.
Impact:
- Plasma actual bicarbonate levels and SDS are lower in children with GHD.
- Bicarbonate SDS evaluation can help predict the likelihood of GHD in short stature patients, particularly when SDS is less than or equal to -1.
Objective:
To study the difference of plasma actual bicarbonate between the children with growth hormone deficiency (GHD) and idopathatic short stature (ISS) and to value the plasma bicarbonate standard deviation scores (SDS) in diagnosis of GHD.
Methods:
Forty-seven short stature children were divided into two groups (GHD and ISS) according to the peak GH response to provocative test. Plasma actual bicarbonate concentrations anion gap (AG), base excess and electrolytes were measured in 47 children with short stature before GH provocative tests.
Results:
The mean plasma actual bicarbonate concentrations, bicarbonate SDS were (22.60+/-1.29)mmol/L and -0.27+/-0.98 respectively in GHD children, which were significantly lower than those of ISS children (P<0.01), whereas AG was higher than that of ISS children [(11.73+/-4.52 vs 7.87+/-1.70) mmol/L], P<0.01. Seventy-two percent of patients with bicarbonate SDS
Conclusion:
Plasma actual bicarbonate concentrations and bicarbonate SDS are lower in patients with GHD than those in patients with idopathatic short stature. Evaluation of plasma bicarbonate SDS of short stature children can predict the probability of GHD, especially when bicarbonate SDS is less than 1 s.