Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pre-mRNA splicing modulations in senescence.

Eran Meshorer1, Hermona Soreq

  • 1Department of Biological Chemistry, the Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Aging Cell
|July 29, 2003
PubMed
Summary

Changes in alternative splicing occur during aging and disease. This review explores genomic and environmental factors influencing splicing and their research implications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.

Fluids and barriers of the CNS·2026
Same author

BLeaching In-cell Single-molecule burstS (BLISS) reveals a small dynamic fraction of HP1α clusters in undifferentiated embryonic stem cells.

bioRxiv : the preprint server for biology·2026
Same author

Complex genotype-phenotype relationships in neurodevelopmental disorders.

Trends in genetics : TIG·2026
Same author

Identifying maximally informative signal-aware representations of single-cell data using the information bottleneck.

Cell systems·2026
Same author

ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection.

Cell death and differentiation·2026
Same author

Author Correction: H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells.

Nature communications·2026

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Alternative splicing is a key regulatory mechanism in gene expression.
  • Dysregulation of alternative splicing is implicated in aging and age-related diseases.
  • Understanding these changes is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To review the genomic and environmental origins of alternative splicing changes in aging.
  • To discuss the research implications of these findings for understanding age-related diseases.

Main Methods:

  • Literature review of studies on alternative splicing in aging.
  • Analysis of genomic and environmental factors affecting alternative splicing.
  • Synthesis of current research on the implications for age-related diseases.

Main Results:

  • Alternative splicing patterns are altered during the aging process.
  • Both genetic predispositions and environmental exposures can influence these splicing alterations.
  • These changes contribute to the pathophysiology of various age-associated conditions.

Conclusions:

  • Alternative splicing is a critical factor in aging and disease development.
  • Further research into the origins and consequences of splicing changes is warranted.
  • Targeting alternative splicing pathways may offer novel therapeutic avenues for age-related diseases.

Related Experiment Videos