Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased ventilation with NiIPPV does not necessarily improve exercise capacity in COPD.

M P Highcock1, J M Shneerson, I E Smith

  • 1The Respiratory Support and Sleep Centre, Papworth Hospital, Papworth Everard, Cambridge, UK. martin.highcock@dbh.nhs.uk

The European Respiratory Journal
|July 29, 2003
PubMed
Summary

Noninvasive intermittent positive-pressure ventilation (NiIPPV) did not improve exercise capacity in COPD patients, despite increasing ventilation. Different ventilator brands showed no significant differences in effectiveness for improving endurance during treadmill exercise.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole genome sequencing-powered ctDNA sequencing for breast cancer detection.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Association of post-operative ctDNA detection with outcomes of patients with early breast cancers.

ESMO open·2024
Same author

Relationship between IHC4 score and response to neo-adjuvant chemotherapy in estrogen receptor-positive breast cancer.

Breast cancer research and treatment·2017
Same author

Hospital outcomes and long-term survival after referral to a specialized weaning unit.

British journal of anaesthesia·2017
Same author

Research needs in breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Digital clubbing: forms, associations and pathophysiology.

British journal of hospital medicine (London, England : 2005)·2016

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Exercise Science

Background:

  • Limited evidence exists on noninvasive intermittent positive-pressure ventilation (NiIPPV) enhancing exercise capacity in chronic obstructive pulmonary disease (COPD).
  • The comparative effectiveness of various ventilators for COPD patients during exercise remains uninvestigated.

Purpose of the Study:

  • To compare the effectiveness of three bilevel pressure support ventilators (Bipap S/T 30, Nippy2, Vpap II ST) via mouthpiece during submaximal treadmill exercise in COPD patients.
  • To assess the impact of NiIPPV on exercise capacity and ventilation parameters in individuals with COPD.

Main Methods:

  • Eight subjects with COPD performed treadmill walks to exhaustion under four conditions: unencumbered, mouthpiece alone, and with each of three different NiIPPV ventilators.

Related Experiment Videos

  • Randomized order of testing was employed to compare exercise distance and physiological responses.

    • Main Results:

    • Exercise distance decreased with mouthpiece use alone (211 m) compared to unencumbered (259 m), and further reduced with NiIPPV (145 m).
    • No significant differences in exercise capacity were observed between the three tested ventilator brands.
    • NiIPPV significantly increased tidal volume and minute ventilation at exercise breakpoint compared to mouthpiece alone, but did not enhance overall exercise capacity.

    Conclusions:

    • Noninvasive intermittent positive-pressure ventilation, when applied via mouthpiece, did not improve exercise capacity in this cohort of COPD patients.
    • Further research is needed to clarify the efficacy of NiIPPV and determine optimal methods for ventilatory assistance in COPD management.