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Tumor angiogenesis inhibitors
S M Kiselev1, S V Lutsenko, S E Severin
1Moscow Research Institute of Medical Ecology, Moscow 117638, Russia. sm_kiselev@mail.ru
Abstract:
Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into neighboring tissues and metastatic growth. Significant progress in the elucidation of mechanisms underlying tumor angiogenesis and the discovery of a great diversity of biomolecules involved in its regulation have culminated in the development of a radically new approach to antitumor therapy based on the search for efficient inhibitors of tumor angiogenesis. This review is devoted to the analysis of action mechanisms and expression of the major endogenous inhibitors involved in regulation of tumor and physiological angiogenesis. The antiangiogenic effects of the majority of currently known synthetic inhibitors are considered in the context of their roles in the main steps of tumor angiogenesis. Possible applications of antiangiogenic therapy in the chemotherapy of cancer diseases are discussed.
Insights
Tumor angiogenesis, the formation of new blood vessels, fuels cancer growth and metastasis. This review analyzes endogenous inhibitors and synthetic drugs targeting tumor angiogenesis for effective cancer therapy.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Tumor angiogenesis is crucial for neoplasm malignant transformation, enabling tumor cell invasion and metastasis.
- Understanding tumor angiogenesis mechanisms has led to novel anti-cancer therapies targeting angiogenesis inhibitors.
- Endogenous and synthetic angiogenesis inhibitors offer potential for cancer treatment.
Purpose of the Study:
- To review the mechanisms of action and expression of major endogenous inhibitors of tumor and physiological angiogenesis.
- To analyze the antiangiogenic effects of synthetic inhibitors in relation to tumor angiogenesis.
- To discuss the potential applications of antiangiogenic therapy in cancer chemotherapy.
Main Methods:
- Literature review of endogenous and synthetic angiogenesis inhibitors.
- Analysis of molecular mechanisms regulating tumor angiogenesis.
- Evaluation of antiangiogenic effects and therapeutic potential.
Main Results:
- Identified key endogenous molecules regulating both physiological and tumor angiogenesis.
- Detailed the mechanisms of action for various synthetic angiogenesis inhibitors.
- Highlighted the role of these inhibitors in blocking critical steps of tumor angiogenesis.
Conclusions:
- Targeting tumor angiogenesis with inhibitors is a promising therapeutic strategy.
- Further research into endogenous and synthetic inhibitors can enhance cancer chemotherapy.
- Antiangiogenic therapy holds significant potential for improving cancer treatment outcomes.