[Local recurrence and distant metastasis after breast-conserving therapy for patients with breast cancer]

To study the relative factors of local recurrence and distant metastasis after breast-conserving therapy (BCT) for patients with breast cancer.

The data on 174 patients with primary breast cancer who had been treated by BCT were analyzed retrospectively. The patients were followed up for 12 to 196 months with a rate of 97.13% (169/174).

Nine patients showed local recurrence and 14 patients, distant metastasis. The 3-year recurrence rate was 3.79% (5/132), the the 5-year metastasis rate was 10.99% (10/91), and the 5-year survival rate was 92.31% (84/91). Those 3-year recurrence rate for patients without radiotherapy (12.12%) was significantly higher than that with radiotherapy (1.01%), (chi(2) = 5.61, P < 0.05). In patients with node-positive, the the 5-year metastasis rate for patients without chemotherapy (44.44%) was higher than that for those with chemotherapy (6.67%), (P < 0.05). Positive marginal status was associated with local recurrence (P < 0.01). Age at diagnosis of patient with breast cancer (

Radiotherapy must be given after BCT. The patients with positive margin should be treated by re-excision or by mastectomy. Those with young age, node- positive and histological grade III should receive adjuvant chemotherapy.