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Apolipoprotein E genotype and temperament: a longitudinal study from infancy to the late teens
Anthony F Jorm1, Margot Prior, Ann Sanson
1Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia. Anthony.Jorm@anu.edu.au
Psychosomatic Medicine
|July 29, 2003
Abstract
Objective:
To replicate an earlier Finnish study by Keltikangas-Järvinen et al. (5) reporting that the APOE genotype is associated with temperamental traits involving increased activity.
Methods:
DNA was collected from 683 Australian children who had participated in a longitudinal study of childhood temperament from 4 to 8 months up to 17 to 18 years. Associations were examined between APOE genotype and a range of measures of activity and hyperactivity.
Results:
No associations were found.
Conclusions:
The earlier Finnish finding could not be replicated despite adequate statistical power.