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Related Experiment Videos

Embolism bubble adhesion force in excised perfused microvessels.

Akira Suzuki1, David M Eckmann

  • 1Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

Anesthesiology
|July 29, 2003
PubMed
Summary

Gas embolism bubble adhesion to vessel walls increases with longer contact times but decreases with endothelium removal. Albumin solutions significantly enhance bubble adhesion, impacting treatment strategies.

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Area of Science:

  • Biomedical Engineering
  • Fluid Mechanics
  • Vascular Biology

Background:

  • Gas embolism poses a significant clinical challenge, with bubble adhesion mechanics poorly understood.
  • Understanding bubble-vessel wall interactions is crucial for developing novel gas embolism treatments.
  • Molecular determinants of bubble adhesion are key to unraveling adhesion forces.

Purpose of the Study:

  • To quantify the adhesion force of microbubbles to the vessel wall.
  • To investigate the influence of bubble residence time on adhesion.
  • To determine the role of the endothelium and perfusate composition in bubble adhesion.

Main Methods:

  • Microbubbles were injected into excised arterioles and allowed to adhere for varying durations (5-30 min).

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  • Adhesion force was measured by increasing inflow pressure until bubble dislodgement.
  • Bubble adhesion force per unit area (K) was calculated based on differential pressure, diameter, and length.

    • Main Results:

    • Adhesion force (K) peaked at 10 min of contact time, decreasing significantly thereafter.
    • Endothelium removal reduced bubble adhesion force at 10 min.
    • The presence of 5% bovine serum albumin markedly increased adhesion force, aligning with in vivo data.

    Conclusions:

    • Microbubble adhesion to the vessel wall is a dynamic process influenced by multiple factors.
    • Bubble residence time, the presence of endothelium, and perfusate composition critically affect adhesion forces.
    • Findings provide insights into the biophysics of gas embolism and potential therapeutic targets.